Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease.

Lymphocytic choriomeningitis virus (LCMV) infection of normal mice results in a fatal immunopathologic meningitis mediated by CD8+ cytotoxic T lymphocytes (CTL). We have previously shown that female beta2-microglobulin-deficient (beta2m-/-) mice, which are also deficient in CD8+ T cells, are susceptible to LCMV-induced immune-mediated meningitis, characterized by significant weight loss and mor...

T-cell Based Vaccine Can Protect against Acquisition of Hiv-1 Infection or Delay Disease Progression in an Effort To

Objective 1: Define the safety and efficacy of the multiclade DNA prime/rAd5 boost VRC candidate HIV-1 vaccine. Objective 2: Define immunological correlates of vaccine-induced protection from HIV-1 acquisition and/or disease progression to advance development of an HIV-1 candidate Objective 1: Determine the structure of a trimeric HIV-1 Envelope spike and delineate how oligomerization influence...

T-cell Based Vaccine Can Protect against Acquisition of Hiv-1 Infection or Delay Disease Progression in an Effort To

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.

Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of congenital infection, but does not prevent the disease altogether. We employed a nonhuman primate model of congenital CMV infection to investigate the ability...

Breastfeeding may protect against persistent stuttering.

PURPOSE This study investigated the hypothesis that breastfeeding in infancy might protect against persistent stuttering in children. METHOD We collected new data from the mothers of current and past participants in the Illinois Stuttering Research Program on their children's feeding history during infancy. We obtained 47 usable responses, for 17 children with persistent stuttering and 30 chi...